Isingeniso se-NAD Pre-Cursor

I-NAD+ iyi-coenzyme ebalulekile, igama layo eliphelele i-nicotinamide adenine dinucleotide. Itholakala kabanzi ngaphakathi kwamaseli futhi ibamba iqhaza ekuphenduleni kwamakhemikhali amaningi abalulekile. I-NAD+ idlala indima ebalulekile ezinqubweni eziningi zebhayoloji, okuhlanganisa amandla e-metabolism, ukuphefumula kwamaselula, ukulungiswa kwe-DNA, ukulotshwa kofuzo, nokuguga. Ingazuza noma ikhulule ama-electron kuyo ngokusebenzisa izinhlobonhlobo zokusabela kwe-biocatalytic. Kule nqubo, ukusabela i-NAD+ engakwazi ukukugqugquzela kufaka phakathi i-redox, ukunciphisa i-carbonyl, ukudluliswa kwe-acyl, njll. Njenge-coenzyme, umsebenzi oyinhloko we-NAD+ ukudlulisa ama-electron nama-ion e-hydrogen ekuphenduleni kwe-enzyme-catalyzed. Phakathi nale nqubo, i-NAD+ yehliselwa ku-NADH, ngaleyo ndlela ihlinzeka ngama-electron nama-hydrogen ions kokunye ukusabela okudingekile kwe-enzyme. I-NAD+ iphinde yaheha ukunakwa kwesayensi okukhulu eminyakeni yamuva nje ngoba kucatshangwa ukuthi iyabandakanyeka enqubweni yokuguga. Ucwaningo luthole ukuthi ngesikhathi senqubo yokuguga, izinga le-NAD+ kumaseli liyehla, futhi ukwengeza i-NAD+ kungakhuthaza i-metabolism yamandla eselula, ukulungiswa kwe-DNA nokubambezeleka ukuguga. Ngaphezu kwalokho, i-NAD+ iphinde yatholakala inendima ebalulekile ekulungiseni umonakalo we-DNA, i-apoptosis, i-enzyme eyenza isebenze kanye nokulawula ukubonakaliswa kofuzo. Njengamanje, abantu benza ucwaningo olunzulu nge-NAD+ kanye neqhaza layo ku-physiology kanye ne-pathology, ukuze bathole okwengeziwe ngemisebenzi nokusetshenziswa kwe-NAD+.