Ukuguga komuntu kuwumthetho wemvelo wendawo yonke. "I-Biochemistry kanye ne-Cell Biology of Aging" ifingqa amashumi eminyaka ocwaningo lokuguga kanye nezimfanelo zokuguga emonakalweni we-oxidative kanye nokwehla kumazinga e-NAD+.
Kungabonakala ukuthi i-NAD+ idlala indima ebalulekile ezintweni eziphilayo, futhi ihlobene eduze nezifo ezithathelwanayo nezifo.
I-NAD+ ibizwa nge-nicotinamide adenine dinucleotide, noma i-coenzyme I ngamafuphi. Ihileleke kakhulu emisebenzini ehlukahlukene eyisisekelo yomzimba ngaphakathi komzimba, ngaleyo ndlela ithinte ukuvuselelwa kwamandla, ukumelana nokulimala kwe-oxidative, ukulungiswa kwe-DNA, ukulawula izakhi zofuzo nama-genomes alawula ukuguga emangqamuzaneni, ukwenza buthaka noma ngisho nokuvala ezinye izakhi zofuzo eziguga, ngaleyo ndlela kubambezeleka ngokuphumelelayo. ukuqhubeka kolayini. Ngezansi, ake sibheke kabanzi:
1.Ukubaluleka kwe-NAD+
Njengenye yama-metabolite abaluleke kakhulu emzimbeni womuntu, i-NAD+ ibisesimweni esizinzile esihlanganisa ukukhiqizwa kwebhayoloji, ukusetshenziswa, ukujikeleza kanye nokuwohloka isikhathi eside.
Kusukela ngeminyaka yama-30s, izinga le-NAD+ emzimbeni womuntu lizokhombisa ukwehla kwezinga njengoba abantu bekhula. Ukwehla kokuqukethwe kwe-NAD+ kumaseli kuzoholela ekwehleni kwekhono lokulungisa i-DNA, kusheshise ukunqwabelana komonakalo we-DNA, bese kuholela ekubhujisweni kwe-NAD+ Okuqukethwe kuqhubeke kuncipha, kwakhe umjikelezo ononya wokuguga ngokushesha nangokushesha.
Sithi i-NAD+ ihileleke ekulungiseni i-DNA ikakhulukazi ngoba iyingxenye yomndeni we-PARP. Nge-NAD+, i-PARP ingadlala indima yayo ehambisanayo. Ngakolunye uhlangothi, i-PARP futhi ingenye “yabathengi” abakhulu be-NAD+ kumaseli. I-NAD+ esetshenziswa yi-PARP iphenduka i-nicotinamide NAM, bese igelezela endleleni yokuhlenga, bese i-NAD+ ihlanganiswa futhi ngosizo lwe-NAMPT, i-NMNAT namanye ama-enzyme. Lapho amaseli engaphansi kwengcindezi (okuhlanganisa nezinqubo zokulungisa i-DNA), amanani amakhulu e-NAD+ ahlanganiswa ngendlela yokuhlenga ukuze kugcinwe ibhalansi phakathi kokunikezwa nokufunwa.
I-NAD+ ibamba iqhaza ekulungiseni i-DNA njenge-Sirtuins substrate
Ama-Sirtuin awumndeni we-protein deacetylase ohlanganisa amalungu angu-7 (SIRT1-SIRT7). I-SIRT1, SIRT6, ne-SIRT7 zikhona ku-nucleus, i-SIRT2 idlala indima ku-cytoplasm, futhi i-SIRT3, SIRT4, ne-SIRT5 amaprotheni e-mitochondrial. Amanye ama-Sirtuin (ikakhulukazi i-SIRT1 kanye ne-SIRT6) adlala indima ebalulekile ekulungiseni i-DNA kanye nemetabolism yamaselula ngemva kokulimala kwe-DNA.
3.NAD+ imetabolism kanye nemisebenzi yomzimba
01. Gcina i-redox homeostasis
Ukugcina ibhalansi yama-intracellular oxidants kanye nama-antioxidants kuyisihluthulelo samaseli ukuze agcine imisebenzi evamile yomzimba. Kodwa-ke, izisusa ezimbi ezinjengokungcola, izinguquko zokudla okunomsoco kanye nokutheleleka kungaphazamisa le bhalansi futhi kubangele ukulimala kwama-macromolecules ephilayo njenge-DNA namaprotheni. Ukwengeza i-NAD+ kungadlala indima yokuvikela i-oxidative ngokwandisa amazinga nemisebenzi ye-glutathione kanye nochungechunge lwama-enzyme e-antioxidant.
02. Gcina ukuzinza kwe-genome
Ukuntuleka kwe-NAD+ kuzodala izithiyo ekulungisweni komonakalo we-DNA, kubangele inani elikhulu lomonakalo we-DNA ukuthi liqongelele, futhi ukwengeza i-NAD+ kungasiza ukulungisa i-DNA.
03. Lawula ukuzivikela komzimba kanye namazinga okuvuvukala
Ngaphezu kokuthi i-NAD+ ngokwayo ikwazi ukwehlisa amazinga okuvuvukala ngokweqile ngokuthuthukisa ukusebenza kwe-lysosomal, i-enzyme ye-NAMPT edingekayo kumetabolism yayo nayo iyingxenye ebalulekile yokulawula ukungatheleleki. Ukwengeza i-NAD+ kusiza ukulawula ukungatheleleki nokuvuvukala.
Umakhalekhukhwini: 86 18691558819
Irene@xahealthway.com
www.xahealthway.com
https://healthway.en.alibaba.com/
Wechat: 18691558819
WhatsApp: 86 18691558819
Isikhathi sokuthumela: Dec-26-2023
