01
I-Urolithin A: Ngemuva kwegama eliyinqaba,Iwumsebenzi wobuciko wokubhubhisa amagciwane i-Urolithin A: Isithuthukisi semvelo esiqinisa amathumbu.
Ngo-1980, i-urolithin A (UA) yatholwa okokuqala endleleni yokuphakela i-ellagic acid (EA). Kusukela ngaleso sikhathi, ukuba khona kwe-UA kuye kwatholwa ezinhlotsheni eziningi, okuhlanganisa izimpukane zezithelo nabantu.Njengelungu lomndeni we-urolithin, i-UA iwukuphuma okuvame kakhulu kwe-EA. Inezakhiwo nezakhiwo ezifanayo futhi iye yacwaningwa kabanzi. Nokho, i-UA ayivamile emgudwini wokuphefumula. Kuphela uma umzimba udla izinto ezicebile ku-polyphenol ellagitannins (ET) noma i-ellagic acid (EA) (efana nehalananda), ngosizo lwemiphumela ethile ye-microbiome, i-UA izokwenziwa ngaphakathi kwesithunzi sangaphambili.
Ngemva kokungena ekujikelezeni kwegazi, i-UA izoguqulwa kancane ibe ama-conjugates (UA-formaldehyde ne-UA-sulfate). Ukuhlolwa kwe-in vitro cell kubonisa ukuthi ama-conjugate e-UA kulesi sigaba alahlekelwe umsebenzi wawo omningi webhayoloji.
Ngeshwa, ukusebenzisa ngokugcwele ama-polyphenol emvelo futhi uwaguqulele ku-UA akulula. Uma sithatha abantu njengesibonelo, ucwaningo lomtholampilo womuntu lwabonisa ukuthi amaphesenti angama-40 abantu angakwazi ukukhiqiza i-UA emzimbeni, futhi le ngxenye ingase yehle ngenxa yezinguquko ezitshalweni zebhaktheriya ezicekeleke phansi ezibangelwa ukuguga. Ngakho-ke, ezinye izazi ziye zaphakamisa ukuthi ukugcwalisa i-UA ngokuqondile kungase kugweme le nkinga.
Inganekwane: I-Ellagitannin (ET) noma i-ellagic acid (EA) ingakhiqiza i-urolithin A (UA) ngaphansi kwesenzo sezitshalo zamathumbu.
02
Iseli “isilawuli sekhwalithi yefekthri yamandla”,Lawula i-mitophagy
Ngakho-ke, ingabe le UA iyindaba nje “yezinto ezingavamile zibalulekile”, noma ingabe inomphumela wokulwa nokuguga wokuthuthukisa impilo yomzimba nokumelana nezimpawu zokuguga? Ekubhekaneni ne-mitochondria, "imboni yamandla" yamaseli, i-UA yanikeza impendulo yayo.
Ukukhuthaza i-autophagy ekhethiwe ye-mitochondria eyonakele kanye nokubuyisela ukungasebenzi kahle kwe-mitochondrial okubangelwa ukuguga yizindlela eziyinhloko zokulawula ze-UA ezitholakala ezinhlotsheni eziningi (ama-nematode, amagundane, abantu, njll.). Lapho i-mitochondria ivezwa ekucindezelekeni kwangaphandle futhi ilimele, i-autophagy iqala ngokwethiyori. I-UA empeleni isebenza njenge-autophagy inducer futhi ibamba iqhaza kakhulu futhi ilawule inqubo ye-mitophagy ngokusebenzisa izindlela ezimbili:
No.1
I-PINK1/i-Parkin encike endaweni yonke indlela Endleleni encike kuyo yonke indawo ye-mitophagy, ngemva kokuba iphrotheni ye-PINK1 ibona i-mitochondria ehlosiwe, iqoqa futhi ifake i-phosphorylate iphrotheni ebopha ubiquitin i-Parkin, igqugquzela ngokuhlanganyela ukutholakala kwamaprotheni e-mitochondrial, ikhulisa amasignali e-autophagy, kanye "nokugijimela" kuma-phagocytes. I-UA yenza kusebenze ukuvezwa kwezakhi zofuzo ezihlobene, ilawula amazinga e-PINK1 namaprotheni e-Parkin, futhi ikhuthaze inqubo ye-autophagy ye-mitochondrial.
No.2
indlela yokuvula i-receptor eqondile
Ngaphezu kokuthembela endleleni ye-PINK1/Parkin, i-mitochondria ingase futhi “ishintshe izindlela” ukuze isebenzise amaprotheni athile esamukeli (njenge-BNIP3) ukuze iqalise ngokuqondile inqubo yokuzenzakalela. I-UA "ayisoze yayeka futhi isebenze ngokuzinzile", ilawula izinga lokuvezwa kwamaphrotheni amamukeli. okwenza kube lula ukunqwabelana endaweni ye-mitochondrial.
Inganekwane: I-UA ingenza i-mitophagy isebenze ngokulawula izindlela ezihlukene.
03.
Phatha izinkinga ze-metabolic ndawonye,Isandiso sempilo se-UA siyavela
Iqondise ukulawulwa kwe-mitochondrial, ukugcina amandla e-homeostasis yomzimba, nokulawula “injini” yamaseli, isithunzi se-UA akulona ize. Ngasikhathi sinye, inani elikhulu lezilingo liqinisekisile ukuthi i-UA inamandla amakhulu ekuthuthukiseni ukuvuvukala okungapheli, izifo zenhliziyo, ukungasebenzi kahle kwemisipha, kanye nezifo ze-neurodegenerative. I-UA, engakaze ikwazi ukunaka imboni kuze kube manje, izwakala njengetshe eliyigugu elifihliwe olwandle.
Ngaphezu komphumela wayo obonakala uyisimangaliso "wokwelapha zonke izifo", ngokwe "isikhathi sokuphila", inkomba ebalulekile yokuhlola yokulwa nokuguga, nakuba i-UA iyinkanyezi ekhulayo, ngempela ithembisa kakhulu. Lapho imodeli ye-organism nematodes iphiwa i-UA isikhathi eside (kusuka esigabeni samaqanda kuya ekufeni), uma kuqhathaniswa neqembu elilawulayo, i-UA yenza kusebenze indlela yabo yokubonisa i-AMPK futhi yathuthukisa kakhulu i-mitophagy, yandisa isikhathi sokuphila se-nematode kufika ku-45.4%!
Inganekwane: I-UA yelula kakhulu isikhathi sokuphila se-C. elegans ngendlela encike kumthamo
Ezivivinyweni ezimbalwa zomtholampilo zabantu, nakuba i-UA ingakahlolwa ngesikhathi sokuphila komuntu, imiphumela yokuhlolwa okukhona mihle kakhulu. I-UA empeleni ilawula impilo ye-mitochondrial kanye neseli emzimbeni. Lapho i-California strawberry powder, ecebile kuma-precursors e-UA, yengezwa ekudleni, isisindo somzimba kanye nezitshalo ezizuzisayo zamathumbu ezihambisana nokuphila isikhathi eside zathuthukiswa ezifundweni ezinempilo. UA's anti-ukuguga uhambo kuwufanele sibheke phambili.
Umakhalekhukhwini: 86 18691558819
Irene@xahealthway.com
www.xahealthway.com
https://healthway.en.alibaba.com/
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WhatsApp: 86 18691558819
Isikhathi sokuthumela: Dec-29-2023
