Inemiphumela evimbelayo ku-Escherichia coli, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, Typhi kanye ne-amoeba. Ngokomtholampilo, isetshenziselwa ikakhulukazi ukubhubhisa izifo namagciwane. Kuphinde kwatholakala ukuthi lo mkhiqizo unomphumela we-anti-arrhythmic. I-Berberine inomsebenzi we-anti-tumor in vitro futhi ingenza ukukhiqizwa kwamaseli e-B16; okufanayo ne-cytarabinei-hydrochlorideinomphumela omuhle ku-vitro.
Inhloso
I-alkaloid ye-isoquinoline. Ifomula yemolekyuli [C20H18NO4]+. Eyaziwa nangokuthi i-berberine. Itholakala ezitshalweni eziningi ezizukulwaneni eziyi-10 nasemindenini emi-4 kubandakanya i-Berberidaceae. I-Berberine ingakwazi ukwethula amakristalu afana nenaliti aphuzi avela ku-diethyl ether. Iphoyinti lokuncibilika 145 ℃. Incibilika emanzini, ayincibiliki ku-benzene, ether ne-chloroform. I-Berberine iyi-alkaloid ye-quaternary ammonium, futhi ukuncibilika kosawoti bayo emanzini kuncane, isibonelo, i-hydrochloride ingu-1:500 kanti i-sulfate ingu-1:30. Amakristalu e-berberine adonswa emanzini noma e-ethanol ehlanjululwe aqukethe ama-molecule angu-5.5 amanzi ayikristalu; uma enziwe amakristalu asuka ku-chloroform, i-acetone noma i-benzene, aqukethe nama-molecule ahambisanayo e-crystallization solvent. I-Berberine ingelashwa nge-alkali ehlukene ukuze ithole izinhlobo ezintathu ezihlukene ze-berberine: ifomu le-quaternary ammonium, ifomu le-aldehyde kanye nefomu lotshwala, phakathi kwalo uhlobo lwe-quaternary ammonium oluzinzile kakhulu. I-Berberine ine-antibacterial effect ku-hemolytic Streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Freundii kanye ne-Shigella dysenteriae, futhi ithuthukisa i-phagocytosis yamaseli amhlophe egazi. I-Berberine hydrochloride (evame ukubizwa ngokuthi i-berberine hydrochloride) isetshenziswe kabanzi ukwelapha isifo sofuba, isifo sohudo, njll., futhi inemiphumela ethile kusifo sofuba, i-scarlet fever, i-acute tonsillitis kanye nezifo zokuphefumula.
i-pharmacology
i-pharmacodynamics
Ine-spectrum ebanzi ye-antibacterial futhi inemiphumela yokulwa namagciwane ezinhlobonhlobo ze-Gram-positive kanye -negative amagciwane e-vitro, okuhlanganisa i-hemolytic Streptococcus, i-Staphylococcus aureus, ne-Vibrio cholerae. I-Meningococci, i-Shigella dyssenteriae, i-typhoid bacilli, i-Diphtheria bacilli, njll. inemiphumela enamandla yokuvimbela. Ziyi-bacteriostatic ekugxilweni okuphansi futhi zibulala inzalo ekugxilweni okuphezulu. Ibuye ibe nemiphumela ethile evimbelayo kumagciwane omkhuhlane, i-amoeba, i-leptospira, kanye nesikhunta esithile sesikhumba. Ukuhlolwa kwe-in vitro kuqinisekisile ukuthi i-berberine ingathuthukisa ikhono le-phagocytic lama-leukocyte kanye nesistimu ye-reticuloendothelial yesibindi. I-Shigella dysenteriae, i-hemolytic Streptococcus, i-Staphylococcus aureus, njll. imelana kalula nalo mkhiqizo. Akukho ukumelana phakathi kwalo mkhiqizo ne-penicillin ne-streptomycin.
I-Pharmacokinetics
Ukumunca kahle ngomlomo. Ngemuva komjovo, ingena ngokushesha izitho nezicubu ezihlukahlukene, futhi ukuhlushwa kwegazi kugcinwa isikhathi esifushane. Ukugcwala kwegazi ngemva komjovo we-intramuscular kuphansi kunesilinganiso esincane sokuvimbela inhibitory. Umuthi usatshalaliswa kabanzi, ikakhulukazi enhliziyweni, emathanjeni, emaphashini nasesibindini. Isikhathi sokugcina ezicutshini sifushane, futhi kusele inani elincane kuphela ngemva kwamahora angu-24. Imithi eminingi igaywa nge-metabolism futhi ikhishwe emzimbeni, futhi ngaphansi kuka-5% kuphela umthamo olawulwayo ukhishwa ngendlela yokuqala kungakapheli amahora angama-48.
Ngokwemibiko yakamuva, kukholelwa ukuthi lo mkhiqizo unganciphisa inani le-pili ebusweni bamagciwane, ukuvimbela amabhaktheriya ukuthi anamathele kumaseli omuntu, futhi unomphumela wokwelapha. Lo mkhiqizo ubuye ube nomthelela ku-Helicobacter futhi unganciphisa i-gastritis, izilonda zesisu kanye ne-duodenal.
Ikhutshaziwe futhi isetshenziswe ngokuqapha
Nakuba ingasetshenziswa ezinganeni, i-contraindicated ezinganeni ezine-hereditary glucose-6-phosphate dehydrogenase dehydrogenase ngoba lo mkhiqizo ungabangela i-hemolytic anemia futhi uholele ku-jaundice.
Ukusabela okubi
(1) Ukusabela okungathandeki ngomlomo kuyivelakancane, kuba nesicanucanu ngezikhathi ezithile, ukuhlanza, ukuqubuka nomkhuhlane wezidakamizwa, okunyamalala ngemva kokuyeka umuthi.
(2) Umjovo womjovo noma ukumnika kungabangela ukusabela okufana ne-vasodilation, ukwehla komfutho wegazi, nokucindezeleka kwenhliziyo. Ezimweni ezimbi kakhulu, i-Aspen syndrome ingenzeka, ngisho nokufa. I-China isimemezele ukuqedwa kwemijovo ehlukahlukene ye-berberine hydrochloride.
Abantu abambalwa banokuphatheka kabi kwesisu noma kwesisu, ukuqunjelwa noma isifo sohudo.
Umakhalekhukhwini: 86 18691558819
Irene@xahealthway.com
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Isikhathi sokuthumela: Apr-15-2024
