Ikakhulukazi mayelana ne-Spermidine ne-Spermidine trihydrochloridecan ocwaningweni

Ikakhulukazi sebenza mayelanaI-Spermidine futhiI-Spermidine trihydrochloridekungaba ocwaningweni

I-Spermidine [N-(3-aminopropyl)-1,4-diaminobutane] iyi-triamine yomugqa egcwele evame ukubhekwa njengemaphakathi ekuhlanganiseni kwe-spermine. Inefomula ye-molecular C1H19N3 kanye ne-molar mass 145.25 g/mol futhi iyi-molecule encane, encibilikayo emanzini, ekwazi ukungena kulwelwesi lwebhayoloji. Kwenzeka kuzo zonke izinto eziphilayo, ngaphandle kokuhlukaniswa kwe-taxonomic.

I-Spermidine ingabopha ezinhlotsheni eziningi zama-molecule, ibenze babe usizo kakhulu. Basekela izinqubo ezihlanganisa ukukhula kwamaseli, ukuzinza kwe-DNA, ukwanda kwamaseli kanye ne-apoptosis. Kubonakala sengathi ama-polyamines asebenza ngendlela efanayo nasezicini zokukhula ngesikhathi sokuhlukaniswa kwamaseli. Yingakho i-spermidine ibalulekile ekukhuleni kwezicubu ezinempilo nokusebenza.

I-1.Izindawo zokulwa nokuvuvukala ze-Spermidine zomdlavuza kanye nempilo yenhliziyo

Ocwaningweni lwango-2016, i-spermidine yatholakala ukuthi ihlehlisa iwashi lokuguga futhi ithuthukise umsebenzi wenhliziyo nemithambo yegazi kumagundane asebekhulile. Ezingeni lesitho, ukwakheka kwenhliziyo nokusebenza ngcono kumagundane amadala anikezwe i-spermidine. I-metabolism nayo yathuthukiswa kulawa magundane ngenxa yokubuyiselwa kwesakhiwo se-mitochondrial kanye nomsebenzi ngemva kokufakwa kwe-spermidine.

2. I-Spermidineesebenza njengo-anti-ukuguga izithako

Mayelana nokuphila isikhathi eside, izifundo eziningi zezilwane zibonise ukuthi ukuthatha i-spermidine kwandisa isikhathi sokuphila futhi kuvimbela i-fibrosis yesibindi kanye ne-hepatocellular carcinoma. Okufanayo kubonakala kuyiqiniso ngokudla okucebile nge-polyamine. Kukhona nobunye ubufakazi bokuthi kwandisa ukumelana nokucindezeleka, futhi ukwehla okuhlobene neminyaka ku-spermidine kusekela ukuthuthukiswa kwesifo esihlobene neminyaka.

3.Spermidine trihydrochloridekungaba rfundisa Ukwehla Kwengqondo

Ucwaningo olushicilelwe kumagazini i-Cell Reports ngo-2021 imininingwane yokuthi i-spermidine yokudla ithuthukisa ukuqonda nokusebenza kwe-mitochondrial ezimpukaneni namagundane, futhi ihlinzeka ngedatha yomuntu engase ibe khona.