I-Coenzyme Q10 iwukuphela kwento ye-coenzyme Q emzimbeni womuntu, eyaziwa nangokuthi ubiquinone. I-Coenzyme Q10 ifakazelwe ukuthi ine-antioxidant, i-radical scavenging yamahhala, i-anti-tumor futhi ithuthukisa imiphumela yokuzivikela komzimba womuntu, ngaleyo ndlela ikhulule ukukhathala futhi ithuthukise amandla okuzivocavoca, kanye nokulwa nokuguga. Nemiphumela ehlukahlukene yezempilo njengokuvikelwa kwenhliziyo nemithambo yegazi.
eyodwa,Imisebenzi ye-Physiological ye-coenzyme Q10
1. Ukukhipha ama-radical mahhala kanye nomsebenzi we-antioxidant (ukubambezela ukuguga kanyebuhle)
I-Coenzyme Q10 ikhona ezifundeni ezimbili: incishisiwe futhi yenziwe nge-oxidized. Phakathi kwazo, i-coenzyme Q10 encishisiwe ifakwa i-oxidized kalula futhi ingavimbela i-peroxidation ye-lipids namaprotheni futhi ikhiphe ama-radicals mahhala. Yehlisa ukucindezeleka kwe-oxidative, okuwumphumela omubi okhiqizwa ama-radicals mahhala emzimbeni futhi kuyisici esibalulekile esiholela ekugugeni nasekuguleni. I-Coenzyme Q10 iyi-antioxidant esebenzayo kanye ne-radical scavenger yamahhala enganciphisa umonakalo obangelwa ingcindezi ye-oxidative.I-Coenzyme Q10 ingathuthukisa i-bioavailability yesikhumba, imise isikhumba, ikhulise ukugcwala kwama-keratinocyte, ithuthukise amandla e-antioxidant wamaseli esikhumba, ivimbele ukuguga kwesikhumba, futhi ifinyelele umphumela wokwelapha ku-dermatitis, induna, izilonda zesikhumba, izilonda zesikhumba nezinye izifo zesikhumba. I-Coenzyme Q10 ingabuye ikhuthaze ukwakheka kwamangqamuzana e-epithelial kanye ne-benigization yezicubu ze-granulation, ivimbele ukwakheka kwezibazi, futhi ikhuthaze ukulungiswa kwezibazi; vimbela umsebenzi we-phosphotyrosinase, uvimbele ukwakheka kwe-melanin namabala amnyama; ukunciphisa ukujula kwemibimbi, ukuthuthukisa ubuthuntu besikhumba; futhi kungandisa ukucaca Ukugxila kwama-amino acid kwandisa umswakama wesikhumba; inomphumela omuhle ekuthuthukiseni ithoni yesikhumba esifiphele, ukunciphisa imibimbi, nokubuyisela ukushelela kwesikhumba kwasekuqaleni, ukunwebeka kanye nezakhiwo zokuswakama.
2. Thuthukisa ukuzivikela komuntu kanye ne-anti-tumor
Kusukela ngo-1970, izifundo ezifanele zabika ukuthi ukuthatha i-coenzyme Q10 kumagundane kungakhuphula umsebenzi wamangqamuzana omzimba omzimba ekubulaleni amagciwane, kuthuthukise ukusabela kwe-antibody, futhi kukhuthaze ukwanda kwenani lama-immunoglobulins namasosha omzimba. Nikbakht et al. wafunda ukuthi lapho abasubathi besilisa bethatha i-Coenzyme Q10 ngemuva kwemiqhudelwano elandelanayo, inani lama-neutrophils ku-plasma yabo lehla kakhulu. Ngakho-ke, bakholelwa ukuthi i-Coenzyme Q10 inenzuzo ukuvikela amasosha omzimba wabasubathi futhi ithuthukise amasosha omzimba. Kubantu abavamile, ukuthatha i-Coenzyme Q10 ngomlomo ngemva kokusebenza ngokweqile kungathuthukisa ukukhathala komzimba futhi kuthuthukise ubungqabavu bomzimba.
Ucwaningo lweminyaka yamuva lubonise ukuthi i-coenzyme Q10, njengesithuthukisi somzimba esingaqondile, ingadlala indima enhle ekuthuthukiseni ukuzivikela komzimba kanye ne-anti-tumors, futhi inomphumela othile womtholampilo kumdlavuza we-metastatic othuthukisiwe.
3. Qinisa amandla enhliziyo futhi uthuthukise amandla obuchopho
I-Coenzyme Q10 ingenye yezinto ezibaluleke kakhulu emzimbeni womuntu. Okuqukethwe kwayo kuphezulu kakhulu ku-myocardium. Uma ishoda, izodala ukungasebenzi kahle kwenhliziyo, ibangele ukungahambi kahle kwegazi, ukunciphisa ikhono lokusebenza kwenhliziyo, futhi ekugcineni kubangele isifo senhliziyo. Imiphumela eyinhloko ye-coenzyme Q10 ku-myocardium ukukhuthaza i-phosphorylation ye-cellular oxidative, ukuthuthukisa i-myocardial energy metabolism, ukunciphisa ukulimala kwe-ischemia ku-myocardium, ukwandisa ukuphuma kwegazi lenhliziyo, ukuthuthukisa ukuminyana okungapheli kanye nokumelana ne-arrhythmias, ngaleyo ndlela kuvikelwe i-myocardium. Thuthukisa ukusebenza kwenhliziyo futhi unikeze amandla anele e-myocardium. Ucwaningo lwezokwelapha lubonisa ukuthi ngaphezu kwe-75% yeziguli zenhliziyo ziye zathuthukisa kakhulu isimo sazo ngemva kokuthatha i-Coenzyme Q10. I-Coenzyme Q10 iyi-activator ye-metabolic engenza kusebenze ukuphefumula kwamaselula, inikeze umoya-mpilo owanele namandla kuma-cardiomyocyte namaseli obuchopho, igcine amangqamuzana esesimweni esihle nesinempilo, futhi ngenxa yalokho avimbele imicimbi yenhliziyo nemithambo yegazi.
4. Lawula i-lipids yegazi
Ngenkathi ehlisa i-lipids yegazi, ama-statins aphinde avimbe ukwakheka okuzimele komzimba kwe-coenzyme Q10. Ngakho-ke, abantu abane-lipids ephezulu yegazi kufanele bathathe i-coenzyme Q10 lapho bethatha ama-statins ukuze bathole umphumela ongcono wokwehlisa i-lipid. I-Coenzyme Q10 inganciphisa okuqukethwe kwe-low-density lipoprotein eyingozi emzimbeni womuntu, ivimbele i-low density lipoprotein ukuthi ingangeni kugebe lamangqamuzana e-endothelial, inciphise ukwakheka kwama-lipids odongeni lwangaphakathi lwemithambo yegazi, futhi ivimbele i-lipids ukuthi yakhe i-atherosclerotic. ama-plaque ku-intima yemithambo yegazi. , ngenkathi ukwandisa umsebenzi we-high-density lipoprotein, ukususa ngokushesha udoti, ubuthi nama-plaque okwakhiwa odongeni lwangaphakathi lwemithambo yegazi, ukulawula i-lipids yegazi nokuvimbela ukwakheka kwe-atherosclerosis.
ezimbili, Ukuphepha kwe-Coenzyme Q10
Umzimba womuntu awunawo amazinga aphezulu e-Coenzyme Q10 ngesikhathi sokuzalwa, kodwa okuqukethwe kufinyelela umvuthwandaba phakathi kweminyaka engama-20. Ngemva kweminyaka engu-25, ikhono lokuhlanganisa i-Coenzyme Q10 liyancipha kancane kancane. Njengoba iminyaka ikhula, i-Coenzyme Q10 ezingxenyeni ezihlukahlukene nezicubu zomzimba iyancipha kancane kancane, futhi i-Coenzyme Q10 enhliziyweni yehla kakhulu. Lapho okuqukethwe kwe-Coenzyme Q10 emzimbeni womuntu kuncipha ngo-25% Ngokuzayo, izifo ezihlukahlukene zizokwenzeka, ngakho-ke ukufakwa kwangaphandle kwe-Coenzyme Q10 kuyadingeka kakhulu. Isici esiphawulekayo se-Coenzyme Q10 ukuthi ayinabo ubuthi, ayinayo i-teratogenic futhi ayinayo imiphumela emibi esobala, futhi iphephe kakhulu ekusetshenzisweni emtholampilo. I-Coenzyme Q10, njengenye yama-coenzymes abaluleke kakhulu emzimbeni womuntu, isetshenziswa kabanzi ekunakekelweni kwezokwelapha.
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Isikhathi sokuthumela: Feb-26-2024
