Ekhuluma ngayoi-berberine , wonke umuntu angase abe ongajwayelekile, kodwa wonke umuntu kufanele azi isisho esivamile: Umuntu oyisimungulu udla ama-coptis – akakwazi ukusho ubuhlungu! Kunjalo, isakhi esibabayo esiyinhloko ku-coptis yi-berberine, okuyi-berberine hydrochloride.
I-Berberine (BBR) iyi-alkaloid ye-isoquinoline - C20H19NO5 ekhishwe ku-Coptis chinensis. Itholakala ezitshalweni zezizukulwane eziyi-10 kanye nemindeni emi-4 kubandakanya neBerberidaceae. Amakristalu aphuzi amise okwenaliti angawa ku-diethyl ether, nendawo yokuncibilika engu-145°C. Ziyancibilika emanzini futhi azincibiliki ku-benzene, i-diethyl ether ne-chloroform.
Ucwaningo lwanamuhla lwezokwelapha luye lwaqinisekisa ukuthi i-berberine inokuhluleka okukhulu kwenhliziyo, i-anti-arrhythmia, ukwehlisa i-cholesterol, ukwanda kwemisipha ebushelelezi elwa ne-vascular, ukuthuthukisa ukumelana ne-insulin, i-anti-platelet, i-anti-inflammatory kanye neminye imiphumela. Ngakho-ke, kungase kube usizo ezifweni zenhliziyo nemithambo yegazi. Amathemba ayo okusebenza abanzi futhi abalulekile adonse ukunaka okwandayo. Ngokocwaningo lwakamuva lomtholampilo, i-berberine inemiphumela emihle ekuvimbeleni nasekwelapheni umfutho wegazi ophakeme, i-hyperlipidemia, isifo sikashukela, i-arrhythmia, izimila nezinye izifo. I-Berberine hydrochloride ibikwe kakhulu ekwehliseni i-lipids yegazi. I-BBR ingalawula ukuvezwa kwe-low-density lipoprotein receptor LDLR futhi ikhuthaze ukumuncwa kwamaprotheni e-LDL ngamaseli esibindi. I-BBR iguqulwa ibe yi-dihydroberberine (dhBBR) nge-nitroreductase ye-intestine flora gut microbiota, iyenze imunce kalula amathumbu. Ngemva kokumuncwa, i-oxidized ibe yi-BBR esicutshini samathumbu bese ingena egazini. Finyelela imiphumela yokwehlisa i-lipid ne-hypoglycemic. I-BBR futhi ingathuthukisa i-metabolism yamandla. Ukuphathwa ngomlomo kwe-BBR kukhuthaza i-gut microbiota ukuthi ikhiqize i-butyrate, engena egazini futhi isebenze kuma-SCFA (ama-short chain fatty acids), ehlisa i-lipids egazini namazinga kashukela egazini.
I-BBR ingakhuthaza ukuvuselelwa kwamaseli e-pancreatic islet futhi inezinzuzo eziningi kunezinye izidakamizwa ezilwa nesifo sikashukela. Izivivinyo zomtholampilo ezifanele ziye zafakazela ukuthi i-berberine ingavimbela i-myocardial fibrosis kumagundane anesifo sikashukela; I-BBR ine-anti-platelet effect, ingakhuphula okuqukethwe kwe-nucleotide kuma-platelet futhi ivimbele ukuhlangana. I-Berberine ehlanganiswe nama-statins idlala indima ebalulekile ekuqiniseni i-plasma trimethylamine oxidation ku-coronary heart disease futhi ivimbele ukwakheka kwe-atherosclerosis.
I-berberine yaseShayina iyindlela ekahle kunezidakamizwa "ze-statin". Njengoba i-berberine ishibhile izikhathi eziningi kunezidakamizwa “zama-statins,” ukutholakala komphumela we-berberine wokwehlisa i-lipid-lipid kunenani elingalindelekile lokuvikela nokwelashwa kwe-hyperlipidemia, isifo sikashukela kanye nesifo senhliziyo.
【Xhumana nathi】
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Isikhathi sokuthumela: Jan-08-2024
